⁶⁸Ga-Labeled Fibroblast Activation Protein Inhibitor PET/CT for the Early and Late Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer Patients: A Prospective Study.

ABSTRACT: ⁶⁸Ga-labeled fibroblast activation protein inhibitor (⁶⁸Ga-FAPI) PET/CT has demonstrated promising clinical results, with a higher SUV_max and tumor-to-background ratio (TBR) in breast cancer (BC) patients than ¹⁸F-FDG PET/CT. Here, we aimed to evaluate the suitability of ⁶⁸Ga-FAPI PET/CT for the early and late prediction of the pathologic response to neoadjuvant chemotherapy (NAC) in BC. Methods: Twenty-two consecutive patients with newly diagnosed BC and an indication for NAC were prospectively included. All patients underwent standard chemotherapy and ⁶⁸Ga-FAPI PET/CT at baseline, after 2 cycles of NAC (PET2), and 1 wk before surgery (PET3). SUV_max was measured in the primary tumor region and positive reg

SUBMITTER: Chen L 

PROVIDER: S-EPMC10690122 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature