Ontology highlight
ABSTRACT:
SUBMITTER: Chahine Z
PROVIDER: S-EPMC10690269 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Chahine Z Z Abel S S Hollin T T Chung J H JH Barnes G L GL Daub M E ME Renard I I Choi J Y JY Pratap V V Pal A A Alba-Argomaniz M M Banks Cas C Kirkwood J J Saraf A A Camino I I Castaneda P P Cuevas M C MC De Mercado-Arnanz J J Fernandez-Alvaro E E Garcia-Perez A A Ibarz N N Viera-Morilla S S Prudhomme J J Joyner C J CJ Bei A K AK Florens L L Ben Mamoun C C Vanderwal C D CD Le Roch K G KG
bioRxiv : the preprint server for biology 20231122
Here we report the discovery of MED6-189, a new analogue of the kalihinol family of isocyanoterpene (ICT) natural products. MED6-189 is effective against drug-sensitive and -resistant <i>P. falciparum</i> strains blocking both intraerythrocytic asexual replication and sexual differentiation. This compound was also effective against <i>P. knowlesi</i> and <i>P. cynomolgi</i>. In vivo efficacy studies using a humanized mouse model of malaria confirms strong efficacy of the compound in animals with ...[more]