Exposure to sounds during sleep impairs hippocampal sharp wave ripples and memory consolidation.

ABSTRACT: Sleep is critical for the consolidation of recent experiences into long-term memories. As a key underlying neuronal mechanism, hippocampal sharp-wave ripples (SWRs) occurring during sleep define periods of hippocampal reactivation of recent experiences and have been causally linked with memory consolidation. Hippocampal SWR-dependent memory consolidation during sleep is often referred to as occurring during an "offline" state, dedicated to processing internally generated neural activity patterns rather than external stimuli. However, the brain is not fully disconnected from the environment during sleep. In particular, sounds heard during sleep are processed by a highly active auditory system which projects to brain regions in the medial temporal lobe, reflecting an anatomical pathway for s

SUBMITTER: Salgado-Puga K 

PROVIDER: S-EPMC10690295 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature