A limbic-predominant amnestic neurodegenerative syndrome associated with TDP-43 pathology.

ABSTRACT: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neuropathologically-defined disease that affects 40% of persons in advanced age, but its associated neurological syndrome is not defined. LATE neuropathological changes (LATE-NC) are frequently comorbid with Alzheimer's disease neuropathologic changes (ADNC). When seen in isolation, LATE-NC have been associated with a predominantly amnestic profile and slow clinical progression. We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome (LANS) that is highly associated with LATE-NC but also other pathologic entities. The LANS criteria incorporate core, standard and advanced features that are measurable in vivo, including older age at evaluation, mild clinical syndrome, disproport

SUBMITTER: Corriveau-Lecavalier N 

PROVIDER: S-EPMC10690340 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature