Congenital and idiopathic scoliosis: clinical and genetic aspects.

ABSTRACT:

Objective

Genetic and environmental factors influencing spinal development in lower vertebrates are likely to play a role in the abnormalities associated with human congenital scoliosis (CS) and idiopathic scoliosis (IS). An overview of the molecular embryology of spinal development and the clinical and genetic aspects of CS and IS are presented. Utilizing synteny analysis of the mouse and human genetic databases, likely candidate genes for human CS and IS were identified.

Design

Review and synteny analysis.

Methods

A search of the Mouse Genome Database was performed for "genes," "markers" and "phenotypes" in the categories Neurological and neuromuscular, Skeleton, and Tail and other appendages. The Online Mendelian Inheritance in Man was used to determine whether eac

SUBMITTER: Giampietro PF 

PROVIDER: S-EPMC1069035 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature