Phenotype plasticity and altered sensitivity to chemotherapeutic agents in aggressive prostate cancer cells.

ABSTRACT: In 2023, approximately 288,300 new diagnoses of prostate cancer will occur, with 34,700 disease-related deaths. Death from prostate cancer is associated with metastasis, enabled by progression of tumor phenotypes and successful extracapsular extension to reach Batson's venous plexus, a specific route to the spine and brain. Using a mouse-human tumor xenograft model, we isolated an aggressive muscle invasive cell population of prostate cancer, called DU145^J7 with a distinct biophysical phenotype, elevated histone H3K27, and increased matrix metalloproteinase 14 expression as compared to the non-aggressive parent cell population called DU145^WT. Our goal was to determine the sensitivities to known chemotherapeutic agents of the aggressive cells as compared to the parent

SUBMITTER: Paxson AI 

PROVIDER: S-EPMC10690371 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature