Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.

ABSTRACT: The immune response is an energy-demanding process that must be coordinated with systemic metabolic changes redirecting nutrients from stores to the immune system. Although this interplay is fundamental for the function of the immune system, the underlying mechanisms remain elusive. Our data show that the pro-inflammatory polarization of Drosophila macrophages is coupled to the production of the insulin antagonist ImpL2 through the activity of the transcription factor HIF1α. ImpL2 production, reflecting nutritional demands of activated macrophages, subsequently impairs insulin signaling in the fat body, thereby triggering FOXO-driven mobilization of lipoproteins. This metabolic adaptation is fundamental for the function of the immune system and an individual's resistance to infection. We d

SUBMITTER: Krejcova G 

PROVIDER: S-EPMC10690471 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature