The Pharmacological Effect of Hemin in Inflammatory-Related Diseases: Protocol for a Systematic Review.

ABSTRACT:

Background

Hemin is a commonly used drug in the treatment of acute attacks of porphyria, due to its capability of restoring normal levels of hemoproteins and respiratory pigments. In addition, this drug has demonstrated the capacity to induce the heme oxygenase (HO) enzyme. At the moment, there are 3 known HO isoenzymes in mammals: HO-1, HO-2, and HO-3. The first of these shows cytoprotective, antioxidant, and anti-inflammatory effects. Currently, medicines used in inflammatory disorders have increased toxicity, especially over longer time frames, which highlights the need to investigate new, safer options. Indeed, the current nonclinical evidence demonstrates the potential that hemin has a significant anti-inflammatory effect in several animal models of inflammation-related diseas

SUBMITTER: Estarreja J 

PROVIDER: S-EPMC10690530 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature