Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles.

ABSTRACT:

Purpose

Molecular ultrasound imaging of tumor vasculature is being actively investigated with microbubble contrast agents targeted to neovasculature biomarkers. Yet, a universal method of targeting tumor vasculature independent of specific biomarkers, or in their absence, would be desirable. We report the use of electrostatic interaction to achieve adherence of microbubbles to tumor vasculature and resulting tumor delineation by ultrasound imaging.

Methods and materials

Microbubbles were prepared from decafluorobutane gas by amalgamation of aqueous micellar medium. Distearoyl phosphatidylcholine (DSPC) and polyethylene glycol (PEG)-stearate were used as microbubble shell-forming lipids; cationic lipid distearoyl trimethylammoniumpropane (DSTAP) was included to introduce posi

SUBMITTER: Diakova GB 

PROVIDER: S-EPMC10690642 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature