An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms.

ABSTRACT:

Objective

Epilepsy and depression share neurobiological origins, and evidence suggests a possible bidirectional relationship that remains poorly understood. This exploratory, cross-sectional study aimed to investigate this relationship by employing magnetic resonance spectroscopic imaging (MRSI) and thermometry (MRSI-t) in patients with temporal lobe epilepsy (TLE) with comorbid depressive symptoms and control participants. This is the first study to combine MRSI and MRSI-t to examine brain temperature and choline abnormalities in regions implicated in seizure onset and depression.

Methods

Twenty-six patients with TLE and 26 controls completed questionnaires and underwent imaging at 3T. Volumetric echo-planar MRSI/MRSI-t data were processed within the Metabolite Imaging and

SUBMITTER: Oates M 

PROVIDER: S-EPMC10690665 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature