Ictal and interictal SPECT with ^99m Tc-HMPAO in presurgical epilepsy. II: Methodological considerations on hyper- and hypoperfusion.

ABSTRACT:

Objective

Single-photon emission computed tomography (SPECT) with the tracer ^99m Tc-HMPAO is a method to visualize the cerebral hyperperfusion during an epileptic seizure and thus localize the epileptogenic zone and seizure propagation. Subtraction of interictal from Ictal SPECT Co-registered to MRI (SISCOM) visualizes areas with relative increases in cerebral blood flow. The purpose of this retrospective study is to explore the added value of visualizing areas of hypoperfusion as well as hyperperfusion, so-called reversed SISCOM.

Methods

Fifty-six patients operated for epilepsy who had been investigated with SISCOM were included in the analysis. The patients were divided into two groups based on seizure duration after tracer injection, above or below 30 s. The pr

SUBMITTER: Prener M 

PROVIDER: S-EPMC10690685 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature