Causal relationship between telomere length and epilepsy: A bidirectional Mendelian randomization study.

ABSTRACT:

Objective

Observational studies have suggested a link between telomere length (TL) and epilepsy, but the direction of the effect and whether it is causal or not is still being debated. The objective of this study was to investigate the causal relationship between TL and epilepsy using Mendelian randomization (MR) analysis.

Methods

We performed a bidirectional two-sample MR analysis using pooled statistics from genome-wide association studies (GWAS) of TL and epilepsy. Additionally, we conducted a replication analysis using data from another GWAS study on epilepsy to validate our findings. The final results were analyzed using five MR methods, with the inverse-variance weighted (IVW) method as the primary outcome. We applied methods such as radial MR, MR pleiotropy residual a

SUBMITTER: Luo X 

PROVIDER: S-EPMC10690705 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature