The prognostic significance of tumor-immune microenvironment in ascites of patients with high-grade serous carcinoma.

ABSTRACT:

Background

High-grade serous carcinoma (HGSC) is often associated with ascites at presentation. Our objective was to quantify immune cells (ICs) in ascites prior to any treatment was given and evaluate their impact on progression-free survival (PFS) and overall survival (OS).

Patients and methods

Forty-seven patients with primary HGSC and ascites were included. Flow-cytometric analysis was performed to detect percentages of CD3⁺ T cells (CD4⁺, CD8⁺, Tregs, and NKT cells), B cells, NK cells (CD56^brightCD16^- and CD56^dimCD16⁺ subsets), macrophages and dendritic cells (DCs). Furthermore, CD103 expression was analyzed on T cells and their subsets, while PD-1 and PD-L1 expression on all ICs. Cut-off of lo

SUBMITTER: Miceska S 

PROVIDER: S-EPMC10690755 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature