Ontology highlight
ABSTRACT:
SUBMITTER: Sandler SE
PROVIDER: S-EPMC10690769 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Sandler Sarah E SE Horne Robert I RI Rocchetti Sara S Novak Robert R Hsu Nai-Shu NS Castellana Cruz Marta M Faidon Brotzakis Z Z Gregory Rebecca C RC Chia Sean S Bernardes Gonçalo J L GJL Keyser Ulrich F UF Vendruscolo Michele M
Journal of the American Chemical Society 20231116 47
Misfolded protein oligomers are of central importance in both the diagnosis and treatment of Alzheimer's and Parkinson's diseases. However, accurate high-throughput methods to detect and quantify oligomer populations are still needed. We present here a single-molecule approach for the detection and quantification of oligomeric species. The approach is based on the use of solid-state nanopores and multiplexed DNA barcoding to identify and characterize oligomers from multiple samples. We study α-s ...[more]