Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges.

ABSTRACT: Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed with an incredible diversity of T cell receptors (TCRs) that theoretically react to the variety of random mutations generated by tumor cells. The outcomes, however, of current clinical trials using TCR-T cell therapies are not very successful especially involving solid tumors. The therapy still faces numerous challenges in the efficient screening of tumor-specific antigens and their cognate TCRs. In this review, we first introduce TCR structure-based antigen recognition and signaling, then describe recent advances in neoantigens and their specific TCR screening technologies, and fina

SUBMITTER: Pang Z 

PROVIDER: S-EPMC10690996 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature