Resident Memory-like CD8⁺ T Cells Are Involved in Chronic Inflammatory and Neurodegenerative Diseases in the CNS.

ABSTRACT:

Background and objectives

Resident memory T (Trm) cells are a unique population that can survive and function in a compartmentalized tissue with inflammatory potential. We aim to investigate the alteration of Trm population in acute/chronic inflammatory and neurodegenerative diseases in the CNS.

Methods

The frequencies of CD4⁺ and CD8⁺ T cells expressing both CD69 and CD103, the markers for Trm cells, were quantified in the peripheral blood and CSF (n = 80 and 44, respectively) in a cross-sectional manner. The transcriptional profile of Trm-like population in the CSF was further analyzed using a public single-cell dataset.

Results

The frequency of CD69⁺CD103⁺CD8⁺ T cells was strikingly higher in the CSF than in th

SUBMITTER: Kimura K 

PROVIDER: S-EPMC10691221 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature