Ontology highlight
ABSTRACT:
SUBMITTER: Dunbar KL
PROVIDER: S-EPMC10691236 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Dunbar Kyle L KL Perlatti Bruno B Liu Nicholas N Cornelius Amber A Mummau Daniel D Chiang Yi-Ming YM Hon Lawrence L Nimavat Monika M Pallas Jason J Kordes Sina S Ng Ho Leung HL Harvey Colin J B CJB
Proceedings of the National Academy of Sciences of the United States of America 20231120 48
With the significant increase in the availability of microbial genome sequences in recent years, resistance gene-guided genome mining has emerged as a powerful approach for identifying natural products with specific bioactivities. Here, we present the use of this approach to reveal the roseopurpurins as potent inhibitors of cyclin-dependent kinases (CDKs), a class of cell cycle regulators implicated in multiple cancers. We identified a biosynthetic gene cluster (BGC) with a putative resistance g ...[more]