The mechanism of Gα_q regulation of PLCβ3-catalyzed PIP2 hydrolysis.

ABSTRACT: PLCβ (Phospholipase Cβ) enzymes cleave phosphatidylinositol 4,5-bisphosphate (PIP2) producing IP3 and DAG (diacylglycerol). PIP2 modulates the function of many ion channels, while IP3 and DAG regulate intracellular Ca²⁺ levels and protein phosphorylation by protein kinase C, respectively. PLCβ enzymes are under the control of G protein coupled receptor signaling through direct interactions with G proteins Gβγ and Gα_q and have been shown to be coincidence detectors for dual stimulation of Gα_q and Gα_i-coupled receptors. PLCβs are aqueous-soluble cytoplasmic enzymes but partition onto the membrane surface to access their lipid substrate, complica

SUBMITTER: Falzone ME 

PROVIDER: S-EPMC10691244 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature