Gut microbiota and common gastrointestinal diseases: a bidirectional two-sample Mendelian randomized study.

ABSTRACT:

Background

Several recent studies have shown an association between gut microbiota and gastrointestinal diseases. However, the causal relationship between gut microbiota and gastrointestinal disorders is unclear.

Methods

We assessed causal relationships between gut microbiota and eight common gastrointestinal diseases using Mendelian randomization (MR) analyses. IVW results were considered primary results. Cochrane's Q and MR-Egger tests were used to test for heterogeneity and pleiotropy. Leave-one-out was used to test the stability of the MR results, and Bonferroni correction was used to test the strength of the causal relationship between exposure and outcome.

Results

MR analyses of 196 gut microbiota and eight common gastrointestinal disease phenotypes showed 62 fl

SUBMITTER: Qiu B 

PROVIDER: S-EPMC10691374 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature