A decline in functional status while awaiting liver transplantation is predictive of increased post-transplantation mortality.

ABSTRACT:

Background

Functional status (FS) is dynamic and changes over time. We examined how changes in FS while awaiting liver transplantation influence post-transplant outcomes.

Methods

Data on adult liver transplants performed in the United States during the MELD era were obtained through September 2020. Patient and graft survival were compared between groups with no change or improved FS, and those with worsening FS.

Results

Of the 90,210 transplant recipients included in the analysis, 39,193 (43%) had worsening FS, which was associated with longer waiting-list time (187 vs. 329 days, p < 0.001) and worse patient survival after liver transplant (1858 vs. 1727 days, p < 0.001). A consistent and dose-dependent relationship was observed for each 10-point decrease in Karnofsky

SUBMITTER: Bezinover D 

PROVIDER: S-EPMC10691403 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature