Metal-organic framework (UiO-66 and UiO-66-NH₂)-based adsorbents for bilirubin removal used in hemoperfusion.

ABSTRACT: Excessive accumulation of bilirubin in patients with hyperbilirubinemia can lead to tissue and organ damage and neurological diseases, and is even life-threatening in severe cases. Hemoperfusion is an effective method for removing bilirubin, but clinically used hemoperfusion adsorbents have unsatisfactory adsorption capacity and kinetics. In order to obtain a safe and efficient bilirubin adsorbent, Zr-based Metal-Organic Framework (MOF) material UiO-66 with high specific surface area and aqueous medium stability was prepared and modified with varying degrees of amination to improve its adsorption capacity. According to adsorption experiments in aqueous solution and simulated plasma, it was confirmed that the unsaturated coordinated zirconium in UiO-66 can effectively induce the aggregation

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10691446 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature