Clustered and diverse transcription factor binding underlies cell type specificity of enhancers for housekeeping genes.

ABSTRACT: Housekeeping genes are considered to be regulated by common enhancers across different tissues. Here we report that most of the commonly expressed mouse or human genes across different cell types, including more than half of the previously identified housekeeping genes, are associated with cell type-specific enhancers. Furthermore, the binding of most transcription factors (TFs) is cell type-specific. We reason that these cell type specificities are causally related to the collective TF recruitment at regulatory sites, as TFs tend to bind to regions associated with many other TFs and each cell type has a unique repertoire of expressed TFs. Based on binding profiles of hundreds of TFs from HepG2, K562, and GM12878 cells, we show that 80% of all TF peaks overlapping H3K27ac signals are in th

SUBMITTER: Zhu I 

PROVIDER: S-EPMC10691539 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature