Dataset Information

Plastic additive components of PM_2.5 increase corrected QT interval: Screening for exposure markers based on airborne exposome.

ABSTRACT: The impact of industrial chemical components of ambient fine particles (e.g. PM_2.5) on cardiovascular health has been poorly explored. Our study reports for the first time the associations between human exposure to complex plastic additive (PA) components of PM_2.5 and prolongation of heart rate-corrected QT (QT_C) interval by employing a screening-to-validation strategy based on a cohort of 373 participants (136 in the screening set and 237 in the validation set) recruited from 7 communities across China. The high-throughput airborne exposome framework revealed ubiquitous occurrences of 95 of 224 target PAs in PM_2.5, totaling from 66.3 to 555 ng m^-3 across the study locations. Joint effects were identified for 9 of the 13 groups of PAs with positive associations with QT_C interval. Independent effect analysis also identified and validated tris(2-chloroisopropyl) phosphate, di-n-butyl/diisobutyl adipate, and 3,5-di-tert-butyl-4-hydroxybenzaldehyde as the key exposure markers for QT_C interval prolongation and changes of selected cardiovascular biomarkers. Our findings highlight the important contributions of airborne industrial chemicals to the risks of cardiovascular diseases and underline the critical need for further research on the underlying mechanisms, toxic modes of action, and human exposure risks.

SUBMITTER: Liu X

PROVIDER: S-EPMC10691654 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Plastic additive components of PM2.5 increase corrected QT interval: Screening for exposure markers based on airborne exposome.

Liu Xiaotu X Wang Yanwen Y Fang Jianlong J Chen Renjie R Sun Yue Y Tang Shuqin S Wang Minghao M Kan Haidong H Li Tiantian T Chen Da D

PNAS nexus 20231123 12

The impact of industrial chemical components of ambient fine particles (e.g. PM2.5) on cardiovascular health has been poorly explored. Our study reports for the first time the associations between human exposure to complex plastic additive (PA) components of PM2.5 and prolongation of heart rate-corrected QT (QTC) interval by employing a screening-to-validation strategy based on a cohort of 373 participants (136 in the screening set and 237 in the validation set) ...[more]

PMID: 38047040

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Project description:BackgroundNumerous studies have documented PM2.5's links with adverse health outcomes. Comparatively fewer studies have evaluated specific PM2.5 components. The lack of exposure measurements and high correlation among different PM2.5 components are two limitations.MethodsWe applied a novel exposure prediction model to obtain annual Census tract-level concentrations of 15 PM2.5 components (Zn, V, Si, Pb, Ni, K, Fe, Cu, Ca, Br, SO42-, NO3-, NH4+, OC, EC) in Massachusetts from 2000 to 2015, to which we matched geocoded deaths. All non-accidental mortality, cardiovascular mortality, and respiratory mortality were examined for the population aged 18 or over. Weighted quantile sum (WQS) regression models were used to examine the cumulative associations between PM2.5 components mixture and outcomes and each component's contributions to the cumulative associations. We have fit WQS models on 15 PM2.5 components and a priori identified source groups (heavy fuel oil combustion, biomass burning, crustal matter, non-tailpipe traffic source, tailpipe traffic source, secondary particles from power plants, secondary particles from agriculture, unclear source) for the 15 PM2.5 components. Total PM2.5 mass analysis and single component associations were also conducted through quasi-Poisson regression models.ResultsPositive cumulative associations between the components mixture and all three outcomes were observed from the WQS models. Components with large contribution to the cumulative associations included K, OC, and Fe. Biomass burning, traffic emissions, and secondary particles from power plants were identified as important source contributing to the cumulative associations. Mortality rate ratios for cardiovascular mortality were of greater magnitude than all non-accidental mortality and respiratory mortality, which is also observed in cumulative associations estimated from WQS, total PM2.5 mass analysis, and single component associations.ConclusionWe have found positive associations between the mixture of 15 PM2.5 components and all non-accidental mortality, cardiovascular mortality, and respiratory mortality. Among these components, Fe, K, and OC have been identified as having important contribution to the cumulative associations. The WQS results also suggests potential source effects from biomass burning, traffic emissions, and secondary particles from power plants.

Dataset Information

Plastic additive components of PM_2.5 increase corrected QT interval: Screening for exposure markers based on airborne exposome.

Publications

Plastic additive components of PM<sub>2.5</sub> increase corrected QT interval: Screening for exposure markers based on airborne exposome.

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