Prevalence of viral DNA in high-grade serous epithelial ovarian cancer and correlation with clinical outcomes.

ABSTRACT:

Introduction

Currently 11 infectious agents are classified as carcinogenic but the role of infectious agents on outcomes of epithelial ovarian cancer is largely unknown.

Objective

To explore the association between infectious agents and ovarian cancer, we investigated the prevalence of viral DNA in primary ovarian cancer tumors and its association with clinical outcomes.

Methods

Archived tumors from 98 patients diagnosed with high-grade serous epithelial ovarian cancer were collected between 1/1/1994 and 12/31/2010. After DNA extraction, Luminex technology was utilized to identify polymerase chain reaction-amplified viral DNA for 113 specific viruses. Demographic data and disease characteristics were summarized using descriptive statistics. We used logistic regression

SUBMITTER: Robertson SE 

PROVIDER: S-EPMC10691703 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature