AimSeg: A machine-learning-aided tool for axon, inner tongue and myelin segmentation.

ABSTRACT: Electron microscopy (EM) images of axons and their ensheathing myelin from both the central and peripheral nervous system are used for assessing myelin formation, degeneration (demyelination) and regeneration (remyelination). The g-ratio is the gold standard measure of assessing myelin thickness and quality, and traditionally is determined from measurements made manually from EM images-a time-consuming endeavour with limited reproducibility. These measurements have also historically neglected the innermost uncompacted myelin sheath, known as the inner tongue. Nonetheless, the inner tongue has been shown to be important for myelin growth and some studies have reported that certain conditions can elicit its enlargement. Ignoring this fact may bias the standard g-ratio analysis, whereas quant

SUBMITTER: Carrillo-Barbera P 

PROVIDER: S-EPMC10691719 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature