Quantifying the effects of vagus nerve stimulation on gastric myoelectric activity in ferrets using an interpretable machine learning approach.

ABSTRACT: Vagus nerve stimulation (VNS) is a potential treatment option for gastrointestinal (GI) diseases. The present study aimed to understand the physiological effects of VNS on gastrointestinal (GI) function, which is crucial for developing more effective adaptive closed-loop VNS therapies for GI diseases. Electrogastrography (EGG), which measures gastric electrical activities (GEAs) as a proxy to quantify GI functions, was employed in our investigation. We introduced a recording schema that allowed us to simultaneously induce electrical VNS and record EGG. While this setup created a unique model for studying the effects of VNS on the GI function and provided an excellent testbed for designing advanced neuromodulation therapies, the resulting data was noisy, heterogeneous, and required speciali

SUBMITTER: Zeydabadinezhad M 

PROVIDER: S-EPMC10691721 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature