Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.

ABSTRACT: Adverse events in early life can modulate the response to additional stressors later in life and increase the risk of developing psychiatric disorders. The underlying molecular mechanisms responsible for these effects remain unclear. Here, we uncover that early life adversity (ELA) in mice leads to social subordination. Using single-cell RNA sequencing (scRNA-seq), we identified cell type-specific changes in the transcriptional state of glutamatergic and GABAergic neurons in the ventral hippocampus of ELA mice after exposure to acute social stress in adulthood. These findings were reflected by an alteration in excitatory and inhibitory synaptic transmission induced by ELA in response to acute social stress. Finally, enhancing the inhibitory network function through transient diazepam treat

SUBMITTER: Kos A 

PROVIDER: S-EPMC10691768 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature