Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review.

ABSTRACT:

Objective

To evaluate the evidence concerning systemic pharmacological treatments for SSc digital ulcers (DUs) to inform the development of evidence-based treatment guidelines.

Methods

A systematic literature review of seven databases was performed to identify all original research studies of adult patients with SSc DUs. Randomized controlled trials (RCTs) and prospective longitudinal observational studies (OBSs) were eligible for inclusion. Data were extracted, applying the patient, intervention, comparison, outcome framework, and risk of bias (RoB) was assessed. Due to study heterogeneity, narrative summaries were used to present data.

Results

Forty-seven studies that evaluated the treatment efficacy or safety of pharmacological therapies were identified among 4250

SUBMITTER: Ross L 

PROVIDER: S-EPMC10691932 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature