Information-Theoretic Analysis of a Model of CAR-4-1BB-Mediated NFκB Activation.

ABSTRACT: Systems biology utilizes computational approaches to examine an array of biological processes, such as cell signaling, metabolomics and pharmacology. This includes mathematical modeling of CAR T cells, a modality of cancer therapy by which genetically engineered immune cells recognize and combat a cancerous target. While successful against hematologic malignancies, CAR T cells have shown limited success against other cancer types. Thus, more research is needed to understand their mechanisms of action and leverage their full potential. In our work, we set out to apply information theory on a mathematical model of NFκB signaling initiated by the CAR following antigen encounter. First, we estimated channel capacity for CAR-4-1BB-mediated NFκB signal transduction. Next, we evaluated the pathwa

SUBMITTER: Tserunyan V 

PROVIDER: S-EPMC10691998 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature