An AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids.
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ABSTRACT:
SUBMITTER: Deininger L
PROVIDER: S-EPMC10692072 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
An AI-based segmentation and analysis pipeline for high-field MR monitoring of cerebral organoids.
Deininger Luca L Jung-Klawitter Sabine S Mikut Ralf R Richter Petra P Fischer Manuel M Karimian-Jazi Kianush K Breckwoldt Michael O MO Bendszus Martin M Heiland Sabine S Kleesiek Jens J Opladen Thomas T Kuseyri Hübschmann Oya O Hübschmann Daniel D Schwarz Daniel D
Scientific reports 20231201 1
Cerebral organoids recapitulate the structure and function of the developing human brain in vitro, offering a large potential for personalized therapeutic strategies. The enormous growth of this research area over the past decade with its capability for clinical translation makes a non-invasive, automated analysis pipeline of organoids highly desirable. This work presents a novel non-invasive approach to monitor and analyze cerebral organoids over time using high-field magnetic resonance imaging ...[more]
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