Metallothionein 3 promotes osteoclast differentiation and survival by regulating the intracellular Zn²⁺ concentration and NRF2 pathway.

ABSTRACT: In osteoclastogenesis, the metabolism of metal ions plays an essential role in controlling reactive oxygen species (ROS) production, mitochondrial biogenesis, and survival, and differentiation. However, the mechanism regulating metal ions during osteoclast differentiation remains unclear. The metal-binding protein metallothionein (MT) detoxifies heavy metals, maintains metal ion homeostasis, especially zinc, and manages cellular redox levels. We carried out tests using murine osteoclast precursors to examine the function of MT in osteoclastogenesis and evaluated their potential as targets for future osteoporosis treatments. MT genes were significantly upregulated upon differentiation from osteoclast precursors to mature osteoclasts in response to receptor activators of nuclear factor-κB (N

SUBMITTER: Arisumi S 

PROVIDER: S-EPMC10692135 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature