Ontology highlight
ABSTRACT:
SUBMITTER: Kopp A
PROVIDER: S-EPMC10692205 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Kopp Anja A Hagelueken Gregor G Jamitzky Isabell I Moecking Jonas J Schiffelers Lisa D J LDJ Schmidt Florian I FI Geyer Matthias M
Nature communications 20231201 1
Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases in the cytosol, the N-terminal domain of GSDMD forms pores in the plasma membrane resulting in cytokine release and eventually cell death. Targeting GSDMD is an attractive way to dampen inflammation. In this study, six GSDMD targeting nanobodies are characterized in terms of th ...[more]