Standardized assays to monitor drug sensitivity in hematologic cancers.

ABSTRACT: The principle of drug sensitivity testing is to expose cancer cells to a library of different drugs and measure its effects on cell viability. Recent technological advances, continuous approval of targeted therapies, and improved cell culture protocols have enhanced the precision and clinical relevance of such screens. Indeed, drug sensitivity testing has proven diagnostically valuable for patients with advanced hematologic cancers. However, different cell types behave differently in culture and therefore require optimized drug screening protocols to ensure that their ex vivo drug sensitivity accurately reflects in vivo drug responses. For example, primary chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) cells require unique microenvironmental stimuli to survive in culture, whi

SUBMITTER: Ayuda-Duran P 

PROVIDER: S-EPMC10692209 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature