Hypothyroid women have persistently higher oxidative stress compared to healthy controls.

ABSTRACT:

Objective

Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) represents whole-body RNA and DNA oxidation, respectively. These biomarkers have only been explored sparsely in patients with thyroid disorders.

Methods

In 45 Danish women with newly diagnosed hypothyroidism, we compared 8-oxoGuo and 8-oxodG before or shortly after initiating levothyroxine with the excretion rates at euthyroidism. We also compared the excretion of 8-oxoGuo and 8-oxodG in the patients after restored euthyroidism with 18 healthy control subjects.

Results

Compared with baseline, none of the biomarkers changed significantly in the patients after becomi

SUBMITTER: Riis KR 

PROVIDER: S-EPMC10692686 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature