Alterations in the intestinal microbiota associated with active tuberculosis and latent tuberculosis infection.

ABSTRACT:

Objectives

To study the characteristics of intestinal microbiota at different stages of Mycobacterium tuberculosis infection.

Methods

Fecal samples of 19 active tuberculosis (ATB) patients, 21 latent tuberculosis infection (LTBI) individuals, and 20 healthy controls (HC) were collected. Gut microbiota of all the participants were analyzed by 16S rDNA sequencing. Clinical information of ATB patients was also collected and analyzed.

Results

Both ATB and LTBI groups showed significant decreases in microbial diversity and decline of Clostridia. For ATB patients, bacteria within phylum Proteobacteria increased. While for LTBI individuals, genera Prevotella and Rosburia enriched. The abundance of Faecalibacterium, Clostridia and Gammapr

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10692819 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature