Muscone ameliorates myocardial ischemia‒reperfusion injury by promoting myocardial glycolysis.

ABSTRACT:

Objective

The incidence of acute myocardial infarction (AMI) is increasing yearly. With the use of thrombolysis or percutaneous coronary intervention (PCI), the mortality rate of acute myocardial infarction has been significantly reduced. However, reperfusion can cause additional myocardial injury. There is still a lack of effective drugs to treat I/R injury, and it is urgent to find new therapeutic drugs.

Methods

In this study, network pharmacology was used to predict potential targets and biological processes involved in Muscone-mediated treatment of acute myocardial infarction. To model ischemia‒reperfusion injury, a hypoxia-reoxygenation model and in vivo ischemia‒reperfusion injury C57BL/6 mice model was constructed. Mice were treated with Muscone i.p. for 4 week

SUBMITTER: Gu X 

PROVIDER: S-EPMC10692826 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature