Whole-Exome Sequencing Among School-Aged Children With High Myopia.

ABSTRACT:

Importance

High myopia (HM) is one of the leading causes of visual impairment worldwide. Genetic factors are known to play an important role in the development of HM.

Objective

To identify risk variants in a large HM cohort and to examine the implications of genetic testing of schoolchildren with HM.

Design, setting, and participants

This cohort study retrospectively reviewed whole-exome sequencing (WES) results in 6215 schoolchildren with HM who underwent genetic testing between September 2019 and July 2020 in Wenzhou City, China. HM is defined as a spherical equivalent refraction (SER) of -6.00 diopters (D) or less. The study setting was a genetic testing laboratory and a multicenter school census. Data were analyzed from July 2021 to June 2022.

Main outcomes and

SUBMITTER: Yu X 

PROVIDER: S-EPMC10692858 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature