Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis.

ABSTRACT:

Background

Lymphopenia is defined as a decrease below normal value (often 1.0 x 10⁹ cells/L) of blood circulating lymphocyte count. In the general population, lymphopenia is associated with an increased risk of hospitalisation secondary to infection, independent of traditional clinical risk factors. In hospital, lymphopenia is associated with increased risk of healthcare-associated infection and mortality. By summarising lymphopenia's prevalence and impact on clinical outcomes, we can identify an at-risk population and inform future studies of immune dysfunction following severe illness.

Methods

Peer-reviewed search strategy was performed on three databases. Primary objective was to summarise the pooled prevalence of lymphopenia. Primary outcome was infection incl

SUBMITTER: Elcioglu ZC 

PROVIDER: S-EPMC10693046 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature