CYP4B1 polymorphisms and the risk of breast cancer in Chinese women: a case-control study.

ABSTRACT:

Background

Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene was abnormally expressed in BC and was associated with the prognosis of BC patients. This study aimed to explore the relationship between CYP4B1 single nucleotide polymorphisms (SNPs) and BC risk in Chinese women.

Methods

A case-control study of 1,143 women (571 patients and 572 healthy individuals) was conducted. Rs2297813 G/T, rs12142787 G/A, and rs3766197 C/T in CYP4B1 were selected and genotyped by MassARRAY system. The relationships between these SNPs and the risk of BC were assessed by logistic regression analysis. In addition, multi-factor dimensionality reduction (MDR) was used to analyze SNP-SNP interactions.

Results

CYP4B1 rs2297

SUBMITTER: Yin Y 

PROVIDER: S-EPMC10693087 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature