Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials.

ABSTRACT:

Purpose

To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest.

Methods

We pooled data from four randomised clinical trials in post-cardiac-arrest patients admitted to the ICU with coma after stable return of spontaneous circulation (ROSC). Admission natremia was categorised as normal (135-145 mmol/L), low, or high. We analysed associations between natremia category and Cerebral Performance Category (CPC) 1 or 2 at 6 months, with and without adjustment on the modified Cardiac Arrest Hospital Prognosis Score (mCAHP).

Results

We included 1163 patients (581 from HYPERION, 352 from TTH48, 120 from COMACARE, and 110 from Xe-HYPOTHECA) with a mean age of 63 ± 13 years and a predominance of males (72.5%). A cardiac

SUBMITTER: Lascarrou JB 

PROVIDER: S-EPMC10693108 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature