Aging gene signature of memory CD8⁺ T cells is associated with neurocognitive functioning in Alzheimer's disease.

ABSTRACT:

Background

Memory CD8⁺ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8⁺ T cells expressing low levels of IL-7 receptor alpha (IL-7Rα^low) and the presence of its gene signature (i.e., IL-7Rα^low aging genes) in peripheral blood of older adults without Alzheimer's disease (AD). Considering age as the strongest risk factor for AD and the recent finding of EM CD8⁺ T cell expansion, mostly IL-7Rα^low cells, in AD, we investigated whether subjects with AD have alterations in IL-7Rα^low aging gene signature, especially in relation to genes possibly associated with AD and disease severity.

Results

We identified a set of 29 candidate genes (i.e., putat

SUBMITTER: Young JJ 

PROVIDER: S-EPMC10693128 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature