Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) has a high incidence and mortality rate despite various treatment options, including ¹²⁵I seed implantation. However, recurrence and radiation resistance remain challenging issues. Hsa_circ_0007895 (circEYA3)-derived from exons 2-6 of EYA3-facilitates the proliferation and progression of pancreatic ductal adenocarcinoma. However, the role of circEYA3 in HCC ¹²⁵I radiation resistance remains unclear. Thus, we aimed to investigate the functions and underlying molecular mechanisms of circEYA3 in HCC under ¹²⁵I and X-ray irradiation conditions.

Methods

CircEYA3 was identified by RNA-seq in patients with HCC before and after ¹²⁵I seed implantation treatment, followed by fluorescence in situ hybr

SUBMITTER: Hu P 

PROVIDER: S-EPMC10693171 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature