Key genes and immune infiltration in chronic spontaneous urticaria: a study of bioinformatics and systems biology.

ABSTRACT:

Background

Chronic spontaneous urticaria (CSU) is defined by the spontaneous occurrence of wheals and/or angioedema for >6 weeks. The pathogenesis involves skin mast cells, but the complex causes of their activation remain to be characterized in detail.

Objectives

To explore disease-driving genes and biological pathways in CSU.

Methods

Two microarray data sets, e.g., GSE57178 and GSE72540, with mRNA information of skin from CSU patients, were downloaded from the Gene Expression Omnibus (GEO) database. An integrated bioinformatics pipeline including identification of differentially expressed genes (DEGs), functional enrichment analysis, protein-protein interaction (PPI) network analysis, co-expression and drug prediction analysis, and immune and stromal cells deconvolu

SUBMITTER: Su W 

PROVIDER: S-EPMC10693338 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature