Causal associations between schizophrenia and cancers risk: a Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have reported inconsistent findings regarding the incidence of cancer in patients with schizophrenia compared to the general population. The causal relationship between schizophrenia and cancer remains unclear and requires further investigation.

Objective

To investigate the causal relationship between schizophrenia and cancer.

Methods

In this study, a two-sample Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association studies to determine the causal relationship. The effect estimates were calculated using the random-effects inverse-variance-weighted method.

Results

We determined a causal relationship between genetic predisposition to schizophrenia and cancer, with schizophreni

SUBMITTER: Zhou K 

PROVIDER: S-EPMC10693432 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature