Design of the formalized and integrated Alzheimer's Disease Ontology and its application in retrieving textual data via text mining.

ABSTRACT: As one of the leading causes for dementia in the population, it is imperative that we discern exactly why Alzheimer's disease (AD) has a strong molecular association with beta-amyloid and tau. Although a clear understanding about etiology and pathogenesis of AD remains unsolved, scientists worldwide have dedicated significant efforts to discovering the molecular interactions linked to the pathological characteristics and potential treatments. Knowledge representations, such as domain ontologies encompassing our current understanding about AD, could greatly assist and contribute to disease research. This paper describes the construction and application of the integrated Alzheimer's Disease Ontology (ADO), combining selected concepts from the former version of the ADO and the Alzheimer's Dis

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10693436 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature