Extramedullary hematopoiesis contributes to enhanced erythropoiesis during pregnancy via TGF-β signaling.

ABSTRACT: Red blood cells are the predominant cellular component in human body, and their numbers increase significantly during pregnancy due to heightened erythropoiesis. CD71⁺ erythroid cells (CECs) are immature red blood cells, encompassing erythroblasts and reticulocytes, constitute a rare cell population primarily found in the bone marrow, although they are physiologically enriched in the neonatal mouse spleen and human cord blood. Presently, the mechanisms underlying the CECs expansion during pregnancy remain largely unexplored. Additionally, the mechanisms and roles associated with extramedullary hematopoiesis (EMH) of erythroid cells during pregnancy have yet to be fully elucidated. In this study, our objective was to examine the underlying mechanisms of erythroid-biased hematopoi

SUBMITTER: Fu Y 

PROVIDER: S-EPMC10693449 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature