Identification of intergenerational epigenetic inheritance by whole genome DNA methylation analysis in trios.

ABSTRACT: Genome-wide association studies have identified thousands of loci associated with common diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic modifications, such as the observed in DNA methylation have been proposed as a mechanism of intergenerational inheritance. To investigate the potential contribution of DNA methylation to the missing heritability, we analysed the methylomes of four healthy trios (two parents and one offspring) using whole genome bisulphite sequencing. Of the 1.5 million CpGs (19%) with over 20% variability between parents in at least one family and compatible with a Mendelian inheritance pattern, only 3488 CpGs (0.2%) lacked correlation with any SNP in the genome, marking them as potential sites for intergenerational epigeneti

SUBMITTER: Diez-Villanueva A 

PROVIDER: S-EPMC10693549 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature