A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis.

ABSTRACT: The incidence of pancreatitis in children has increased over the past two decades. With advances in molecular biological techniques and clinical research, genetic variations have emerged as a pivotal etiological factor in pediatric pancreatitis. This review aims to summarize recent clinical research advancements in understanding pediatric pancreatitis caused by various gene mutations. As of the year 2020, researchers had identified 12 genes implicated in the pathogenesis of pancreatitis. These genes primarily contributed to the development of pancreatitis through three mechanisms. Pancreatitis resulting from these gene mutations exhibits several distinct characteristics, including early onset, a heightened risk of developing pancreatic duct stones, rapid disease progression, and a signific

SUBMITTER: Yu B 

PROVIDER: S-EPMC10693666 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature