Systematic review and meta-analysis of oxidative stress and antioxidant markers in recurrent aphthous stomatitis.

ABSTRACT:

Background

We performed this systematic review and meta-analysis to synthesize all studies that reported the level of oxidative and antioxidative markers in recurrent aphthous stomatitis (RAS) patients compared to controls.

Methods

We registered our study in PROSPERO (CRD42023431310). PubMed, ProQuest, Scopus, EMBASE, Google Scholar, and Web of Science were searched to find relevant publications up to June 5, 2023. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated. We included 30 articles after multiple stags of screening.

Results

We found that erythrocyte superoxide dismutase and Glutathione peroxidase activity were significantly lower in patients with RAS compared to healthy controls (SMD = - 1.00, 95%CI = -1.79 to -0.21, p

SUBMITTER: Ghasemi S 

PROVIDER: S-EPMC10693709 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature