Gene mutation analysis of oral submucous fibrosis cancerization in Hainan Island.

ABSTRACT:

Objective

The sequencing panel composed of 61 target genes was used to explore the related mutation genes of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) cancerization, so as to provide a theoretical basis for the early diagnosis of oral submucous fibrosis cancerization, find the most important mutations in OSF cancerization, and more targeted prevention of OSF cancerization.

Methods

A total of 74 clinically diagnosed samples were included, including 36 cases of OSCC and 38 cases of OSF cancer patients. DNA was extracted, and targeted gene panel sequencing technology was used to analyze the gene frequency of pathogenic mutation sites in clinical samples.

Results

Gene panel sequencing analysis showed that there were 69 mutations in 18 genes in

SUBMITTER: Li B 

PROVIDER: S-EPMC10693820 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature